{"id":959,"date":"2026-01-21T15:30:22","date_gmt":"2026-01-21T14:30:22","guid":{"rendered":"https:\/\/coimbraprotokoll.de\/coimbraprotokoll\/"},"modified":"2026-08-24T14:59:52","modified_gmt":"2026-08-24T12:59:52","slug":"coimbraprotokoll","status":"publish","type":"page","link":"https:\/\/coimbraprotokoll.de\/en\/coimbraprotokoll\/","title":{"rendered":"CoimbraProtokoll"},"content":{"rendered":"\t\t
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The Coimbra Protocol at a Glance<\/h1>\t\t\t\t<\/div>\n\t\t\t\t
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What is the Coimbra Protocol?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t
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The Coimbra Protocol describes a medically supervised orthomolecular therapy that uses ultra-high-dose vitamin D against autoimmune diseases.<\/p>

In doing so, “it is not disease XY that is treated; rather, the immune system is brought back into its natural balance by compensating for a genetically determined impairment in vitamin D utilisation,” as Dr Coimbra puts it.<\/p>

In our experience, every autoimmune process responds to some degree to ultra-high-dose vitamin D therapy. Certain nutritional supplements, stress prevention and dietary adjustments support its success.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t

\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t<\/path><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\tThe Coimbra Protocol at a Glance (Download)<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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How did the Coimbra Protocol come about?\n<\/h2>\t\t\t\t<\/div>\n\t\t\t\t
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The Brazilian doctor Dr Cicero G. Coimbra developed this ultra-high-dose therapy from 2002 onwards in his practice, together with patients, and focused his university research on it.<\/p>

He discovered by chance that under higher doses of vitamin D, autoimmune diseases of the skin came to a halt. Even higher doses were able to help his patients with various other autoimmune diseases. In this way, by 2009 he had developed an effective and, at the same time, side-effect-free ultra-high-dose therapy, which has become established as the “Coimbra Protocol”.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Why is vitamin D so important?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t
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Vitamin D is not actually a vitamin but a hormone precursor that regulates the immune system. It also controls the absorption of calcium and promotes its incorporation into bones and teeth. Vitamin D influences physical performance, the hormone balance and mental wellbeing. It plays an essential role in the treatment of cancer and cardiovascular diseases, and during pregnancy.<\/p>

Before vitamin D can regulate the immune system, it must pass through several steps. The biologically inactive form of vitamin D is cholecalciferol, as it is formed in our skin through UV-B sunlight and measured in the blood. It is converted enzymatically, mainly in the liver and kidneys, into calcitriol, the biologically active form. Calcitriol must enter the cell via the vitamin D receptor. Only there does it act to regulate gene expression and the immune system.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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What role does vitamin D play in autoimmune diseases?\n<\/h2>\t\t\t\t<\/div>\n\t\t\t\t
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Dr Coimbra speaks of an “individual vitamin D resistance” in autoimmune diseases, which can be explained by changes in individual sections of the DNA. These so-called single nucleotide polymorphisms disrupt the formation, conversion or utilisation of vitamin D. As a result, the immune system is not adequately supplied with activated vitamin D, which it urgently needs in order to regulate itself. On the one hand, this can lead to a weakened defence; on the other hand, to excessive inflammation that favours autoimmune processes.<\/p>

Dr Coimbra found that individually varying daily doses of vitamin D can overcome this utilisation impairment. As soon as enough active vitamin D (calcitriol) reaches the cell, the immune system stabilises. It stops the autoimmune reaction and strengthens the natural defence against pathogens.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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How does the treatment work?\n<\/h2>\t\t\t\t<\/div>\n\t\t\t\t
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At first, appointments with the trained protocol doctor take place at intervals of three, and later six, months. From the third year onwards, an annual check-up is sufficient, each time with current blood and urine values.<\/p>

These appointments ensure the patient’s safety and serve to find the correct individual vitamin D dose that is needed for the optimal effect and the fastest possible halting of the disease. Should unusual changes occur in the metabolism, the doctor can detect and correct this early, before symptoms appear.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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What are cofactors?\n<\/h2>\t\t\t\t<\/div>\n\t\t\t\t
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The greater part of the Coimbra Protocol’s effect goes back to compensating for the genetically determined impairment in vitamin D utilisation. The body needs certain nutrients in order to convert vitamin D enzymatically into its hormonally active form. These are the orthomolecular cofactors, in particular magnesium and vitamin B2. Further supplements such as omega-3 fatty acids, chromium, zinc, selenium and choline help to reduce inflammatory processes, normalise immune function and optimise cellular metabolism.<\/p>

Another, non-material cofactor is good stress management, since an excessive stress response of the brain and hormone system also disrupts the regulation of the immune system.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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What adjustments to diet and lifestyle are needed?\n<\/h2>\t\t\t\t<\/div>\n\t\t\t\t
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Vitamin D increases the absorption of calcium from food. To ensure that not too much calcium enters the blood, the following measures are necessary:<\/p>