{"id":992,"date":"2026-01-21T16:51:12","date_gmt":"2026-01-21T15:51:12","guid":{"rendered":"https:\/\/coimbraprotokoll.de\/wissenschaftliche-informationen\/"},"modified":"2026-08-24T15:03:30","modified_gmt":"2026-08-24T13:03:30","slug":"scientific-information","status":"publish","type":"page","link":"https:\/\/coimbraprotokoll.de\/en\/scientific-information\/","title":{"rendered":"Scientific Information"},"content":{"rendered":"\t\t
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Scientific Information<\/h1>\t\t\t\t<\/div>\n\t\t\t\t
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Study \"The Coimbra Protocol in MS\"<\/h4>\t\t\t\t<\/div>\n\t\t\t\t
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The first study on the long-term safety and efficacy of ultra-high-dose vitamin D therapy according to the Coimbra Protocol was carried out until December 2025 at the NeuroCure Research Center of the Charit\u00e9 University Hospital in Berlin.<\/p>

The observational study “The Coimbra Protocol in MS”, led by Prof. Friedemann Paul, enrolled 100 patients with relapsing-remitting multiple sclerosis who were at the start of their treatment with a certified protocol doctor.<\/p>

The participants’ data were compared with similar cases from the Charit\u00e9’s ongoing study register, in order to document efficacy compared with pharmacological baseline therapies or treatment-na\u00efve courses.<\/p>

This independent, donation-funded study came about on our initiative, as we \u2014 the non-profit Coimbraprotokoll UG \u2014 are committed to research and scientific documentation. In this way we help to ensure that the Coimbra Protocol becomes recognised and widely known as a therapy for autoimmune diseases.<\/p>

We expect the study to be published during the course of 2026.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t

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Quelle: C. Carlberg \"Nutrigenomics of Viatmin D\" (https:\/\/pubmed.ncbi.nlm.nih.gov\/30901909\/)<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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Current state of research<\/h4>\t\t\t\t<\/div>\n\t\t\t\t
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\u00a0According to the current state of research, impaired vitamin D utilisation and activation are attributable to single nucleotide polymorphisms (abbreviated SNP). This can lead to disturbances in the formation, activation or binding of vitamin D to the cell receptor. Since vitamin D is an important immune regulator, disturbances of the immune system follow from this.<\/p>

The fundamentals of gene expression, or epigenetics, through vitamin D have been researched by, among others, Prof. Carsten Carlberg. In his work he has demonstrated that a part of the world’s population, because of their SNPs, needs much higher vitamin D blood levels in order to maintain healthy immune system function.<\/p>

As early as 2002, Dr Coimbra put forward the theory of a “vitamin D utilisation impairment” and researched it in his practice and at the University of S\u00e3o Paulo.<\/p>

In 2013, he and his team published a study on the use of ultra-high-dose vitamin D therapy according to the Coimbra Protocol in patients with vitiligo and psoriasis. In it, he explained the scientific basis of the Coimbra Protocol’s effect on the immune system. According to Dr Coimbra, this mechanism of action applies to all diseases at whose root lies a derailment of the immune system’s TH and Treg cells. Since this generally applies to autoimmune diseases, this means that ultra-high-dose vitamin D therapy according to the Coimbra Protocol is effective in all autoimmune diseases.<\/p>

A pilot study to assess the impact of prolonged administration of high daily doses of vitamin D on the clinical course of vitiligo and psoriasis, Finamor, Coimbra et al. 2013<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t

\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t<\/path><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\tLink to the article<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t
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Publications and studies on vitamin D & autoimmune diseases<\/h4>\t\t\t\t<\/div>\n\t\t\t\t
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Safety Data in Patients with Autoimmune Diseases during Treatment with High Doses of Vitamin D3 According to the \u201cCoimbra Protocol\u201d<\/strong>
First international publication on the safety of the Coimbra Protocol
-> Link to the publication<\/a><\/strong><\/p>

Does vitamin D slow disease activity in early-stage multiple sclerosis?<\/strong>
-> Download study (german)<\/a>\u00a0<\/strong><\/p>

Serum vitamin D levels as a biomarker in patients with autoimmune uveitis and their possible correlation with disease activity<\/strong>
Karine Koller, Kimble Matos Teixeira Fonseca, Kelsy N. Areco, Yuslay Fern\u00e1ndez-Zamora, Luci Meire Pereira Silva, Ricardo Pedro Casaroli-Marano, Cicero Galli Coimbra & Cristina Muccioli
-> Download study (german)<\/a><\/strong>
-> Download study (english)<\/strong><\/a><\/p>

Vitamin D Resistance as a Possible Cause of Autoimmune Diseases:<\/strong>
A Hypothesis Confirmed by a Therapeutic High-Dose Vitamin D Protocol. Current study (published on 7 April 2021):
-> Link to the study<\/strong><\/a><\/p>

Vitamin D and Multiple Sclerosis: A Comprehensive Review, 2018:<\/strong>
-> Link to the study<\/strong><\/a><\/p>

Role of gene polymorphisms in vitamin D metabolism and in multiple sclerosis.<\/strong>
-> Link to the study<\/strong><\/a><\/p>

Vitamin D Promotes Remyelination (\u2026)
-> Link to the study<\/a> <\/strong><\/p>

Vitamin D and remyelination in multiple sclerosis<\/strong>
-> Link to the study<\/strong><\/a><\/p>

Vitamin D supplementation in multiple sclerosis \u2013 Can be done something more?<\/strong>
-> Link to the study<\/strong><\/a><\/p>

1,25-(OH)2D3\/Vitamin D receptor alleviates systemic lupus erythematosus by downregulating Skp2 and upregulating p27<\/strong>
-> Link to the study<\/strong><\/a><\/p>

Immunomodulatory and Immunosuppressive roles of 1\u03b1,25(OH)2D3 in Autoimmune Diseases<\/strong>
-> Link to the study<\/strong><\/a><\/p>

Modulatory Effects of 1,25-Dihydroxyvitamin D3 on Human B Cell Differentiation
-> Link to the study<\/a><\/strong><\/p>

Nutrigenomics of Vitamin D, C. Carlberg 2019<\/strong>
-> Link to the study<\/strong><\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Please support us with a donation<\/h2>

Help us raise awareness of the Coimbra Protocol \u2013 with a donation or by sharing information.
Thank you so much!<\/p>\t\t<\/div>\n\t\t\t\t\t

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Scientific Information Study “The Coimbra Protocol in MS” The first study on the long-term safety and efficacy of ultra-high-dose vitamin D therapy according to the Coimbra Protocol was carried out until December 2025 at the NeuroCure Research Center of the Charit\u00e9 University Hospital in Berlin. The observational study “The Coimbra Protocol in MS”, led by […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"footnotes":""},"class_list":["post-992","page","type-page","status-publish","hentry"],"yoast_head":"\nCoimbra Protocol Studies & Scientific Information<\/title>\n<meta name=\"description\" content=\"Studies and research on the Coimbra Protocol and vitamin D in autoimmune diseases, including the Charit\u00e9 MS study and key publications.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/coimbraprotokoll.de\/en\/scientific-information\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Coimbra Protocol Studies & Scientific Information\" 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