Scientific Information

 According to the current state of research, impaired vitamin D utilisation and activation are attributable to single nucleotide polymorphisms (abbreviated SNP). This can lead to disturbances in the formation, activation or binding of vitamin D to the cell receptor. Since vitamin D is an important immune regulator, disturbances of the immune system follow from this.

The fundamentals of gene expression, or epigenetics, through vitamin D have been researched by, among others, Prof. Carsten Carlberg. In his work he has demonstrated that a part of the world’s population, because of their SNPs, needs much higher vitamin D blood levels in order to maintain healthy immune system function.

As early as 2002, Dr Coimbra put forward the theory of a “vitamin D utilisation impairment” and researched it in his practice and at the University of São Paulo.

In 2013, he and his team published a study on the use of ultra-high-dose vitamin D therapy according to the Coimbra Protocol in patients with vitiligo and psoriasis. In it, he explained the scientific basis of the Coimbra Protocol’s effect on the immune system. According to Dr Coimbra, this mechanism of action applies to all diseases at whose root lies a derailment of the immune system’s TH and Treg cells. Since this generally applies to autoimmune diseases, this means that ultra-high-dose vitamin D therapy according to the Coimbra Protocol is effective in all autoimmune diseases.

A pilot study to assess the impact of prolonged administration of high daily doses of vitamin D on the clinical course of vitiligo and psoriasis, Finamor, Coimbra et al. 2013